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Issue 17, 2017
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Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

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Abstract

A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle–cell platform towards mammary tumors is assessed in vitro. The efficacy of this platform for anticancer therapy is shown against mammary tumor cells by inducing the release of doxorubicin only when the cell vehicles are exposed to ultrasound.

Graphical abstract: Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

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Publication details

The article was received on 13 Feb 2017, accepted on 23 Mar 2017 and first published on 24 Mar 2017


Article type: Paper
DOI: 10.1039/C7NR01070B
Citation: Nanoscale, 2017,9, 5528-5537
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    Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy

    J. L. Paris, P. de la Torre, M. Victoria Cabañas, M. Manzano, M. Grau, A. I. Flores and M. Vallet-Regí, Nanoscale, 2017, 9, 5528
    DOI: 10.1039/C7NR01070B

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