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Carbon nanowalls: A new versatile graphene based interface for laser desorption/ionization-mass spectrometry detection of small compounds in real samples.

Abstract

Carbon nanowalls, vertically aligned graphene nanosheets, attract attention owing to their tunable band-gap, high conductivity, high mechanical robustness, high optical absorbance and other remarkable properties. In this paper, we report for the first time, the use of hydrophobic boron-doped carbon nanowalls (CNWs) for laser desorption/ionization of small compounds and their subsequent detection by mass spectrometry (LDI-MS). The proposed method offers sensitive detection of various small molecules in absence of organic matrix. The CNWs were grown by microwave plasma enhanced chemical vapor deposition (MW-PECVD), using a boron-carbon gas flow ratio of 1200 in H2/CH4 plasma, on silicon <100> wafer. The hydrophobicity of the surface offers a straightforward MS sample deposition, consisting in drop casting solutions of analytes and drying in air. Limit of detections in the picomolar and femtomolar range (25 fmol/µl for neurotensin) were achieved for different types of compounds (fatty acids, lipids, metabolites, saccharides and peptides) having clinical or food industry interests. This rapid and sensitive procedure can also be used for quantitative measurements without internal standards with RSDs <19%, as in the case of glucose in either aqueous solutions (LOD=0.32±0.02 pmol), blood serum or soft drinks, as well. Moreover, melamine (63±8.19 ng/µL), a toxic compound, together with creatinine and paracetamol, were detected in urine samples, while lecithin was detect in food supplements.

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Publication details

The article was received on 13 Feb 2017, accepted on 07 Jun 2017 and first published on 09 Jun 2017


Article type: Paper
DOI: 10.1039/C7NR01069A
Citation: Nanoscale, 2017, Accepted Manuscript
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    Carbon nanowalls: A new versatile graphene based interface for laser desorption/ionization-mass spectrometry detection of small compounds in real samples.

    I. S. Hosu, M. Sobaszek, M. Ficek, R. Bogdanowicz, H. Drobecq, L. Boussekey, A. Barras, O. Melnyk, R. Boukherroub and Y. Coffinier, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR01069A

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