Jump to main content
Jump to site search


Confinement-Driven Organization of a Histone-Complexed DNA Molecule in a Dense Array of Nanoposts

Abstract

The first step in the controlled storage of lengthy DNA molecules is to keep DNA molecules sep- arated while integrated in micrometer-sized space. Here, we present hybrid Monte Carlo simulations of a histone-complexed DNA (hcDNA) molecule confined in a dense array of nanoposts. Depending on the nanopost dimension, a single, 8.7 kilobase-pair hcDNA molecule is either localized and elongated in a single inter-post space surrounded by four nanoposts or spread over several inter-post spaces through passages between two neighboring nanoposts. The conformational change of a hcDNA molecule is interpreted in terms of competitive effects of confinements in the inter-post and passage spaces. We propose that, by elaborately designing nanopost arrays, the competitive confinement effects can be adjusted such that each hcDNA molecule is localized in a single inter-post space, and thereby multiple hcDNA molecules can be physically separated from each other while stored together in the nanopost array.

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Feb 2017, accepted on 13 Apr 2017 and first published on 13 Apr 2017


Article type: Paper
DOI: 10.1039/C7NR00859G
Citation: Nanoscale, 2017, Accepted Manuscript
  •   Request permissions

    Confinement-Driven Organization of a Histone-Complexed DNA Molecule in a Dense Array of Nanoposts

    H. Joo and J. S. Kim, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR00859G

Search articles by author