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Issue 15, 2017
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Nanomaterial-based bone regeneration

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Abstract

Bone diseases/injuries have been driving an urgent quest for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create suitable microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress in the development of nanomaterials which can promote bone regeneration through bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factor-related mimicking) is summarized. The nanoeffects of nanomaterials on the regulation of bone-related biological functions are highlighted. How to prepare nanomaterials with combinative bone-biomimicry features according to the bone healing process is prospected in order to achieve rapid bone regeneration in situ.

Graphical abstract: Nanomaterial-based bone regeneration

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Publication details

The article was received on 04 Feb 2017, accepted on 10 Mar 2017 and first published on 14 Mar 2017


Article type: Review Article
DOI: 10.1039/C7NR00835J
Citation: Nanoscale, 2017,9, 4862-4874
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    Nanomaterial-based bone regeneration

    Y. Li and C. Liu, Nanoscale, 2017, 9, 4862
    DOI: 10.1039/C7NR00835J

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