Nanomaterials-based Bone Regeneration
Bone diseases/injuries have been driving an urgent request for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create proper microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress on development of nanomaterials which can promote bone regeneration in a bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factors-related mimicking) is summarized. The nanoeffects of nanomaterials on the regulation of bone-related biological functions are highlighted. How to prepare nanomaterials with combinative bone-biomimicry features according to bone healing process is prospected in order to achieve rapid bone regeneration in situ.