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Nanomaterials-based Bone Regeneration

Abstract

Bone diseases/injuries have been driving an urgent request for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create proper microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress on development of nanomaterials which can promote bone regeneration in a bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factors-related mimicking) is summarized. The nanoeffects of nanomaterials on the regulation of bone-related biological functions are highlighted. How to prepare nanomaterials with combinative bone-biomimicry features according to bone healing process is prospected in order to achieve rapid bone regeneration in situ.

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Publication details

The article was received on 04 Feb 2017, accepted on 10 Mar 2017, published on 14 Mar 2017 and first published online on 14 Mar 2017


Article type: Review Article
DOI: 10.1039/C7NR00835J
Citation: Nanoscale, 2017, Accepted Manuscript
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    Nanomaterials-based Bone Regeneration

    Y. Li and C. Liu, Nanoscale, 2017, Accepted Manuscript , DOI: 10.1039/C7NR00835J

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