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Issue 13, 2017
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Yolk–shell nanostructured Fe3O4@C magnetic nanoparticles with enhanced peroxidase-like activity for label-free colorimetric detection of H2O2 and glucose

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Abstract

Herein, we have developed a simple and facile method to synthesize yolk–shell nanostructured Fe3O4@C nanoparticles (NPs) as a multifunctional biosensing platform for the label-free colorimetric detection of H2O2 and glucose. It was demonstrated that Fe3O4@C yolk–shell nanostructures (YSNs) retained the magnetic properties that can be used for separation and concentration. Also importantly, the Fe3O4@C YSNs exhibited an intrinsic peroxidase-like activity that could quickly catalyze the enzyme substrate in the presence of H2O2 and produce a blue color. Compared to other similar ferric oxide-based NPs with different structures, Fe3O4@C YSNs exhibited greatly enhanced catalytic activities due to their unique structural features. Moreover, steady-state kinetics indicated the catalytic behaviors in agreement with the classic Michaelis–Menten models. Taking advantage of the high catalytic activity, Fe3O4@C YSNs were employed as novel peroxidase mimetics for label-free, rapid, sensitive, and specific colorimetric sensing of H2O2 and glucose, suggesting that Fe3O4@C YSNs have the potential for construction of portable sensors in the application of point-of-care (POC) diagnosis and on-site tests.

Graphical abstract: Yolk–shell nanostructured Fe3O4@C magnetic nanoparticles with enhanced peroxidase-like activity for label-free colorimetric detection of H2O2 and glucose

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Publication details

The article was received on 04 Feb 2017, accepted on 03 Mar 2017 and first published on 10 Mar 2017


Article type: Paper
DOI: 10.1039/C7NR00819H
Citation: Nanoscale, 2017,9, 4508-4515
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    Yolk–shell nanostructured Fe3O4@C magnetic nanoparticles with enhanced peroxidase-like activity for label-free colorimetric detection of H2O2 and glucose

    N. Lu, M. Zhang, L. Ding, J. Zheng, C. Zeng, Y. Wen, G. Liu, A. Aldalbahi, J. Shi, S. Song, X. Zuo and L. Wang, Nanoscale, 2017, 9, 4508
    DOI: 10.1039/C7NR00819H

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