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Issue 12, 2017
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A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex

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Abstract

Herein, we report a novel approach for the design of a colorimetric aptasensor based on functionalized gold nanoparticle probes. This approach relies on the conjugation of nanoparticles by two functional DNA and RNA hairpins that engage specific kissing (loop–loop) interactions in response to the addition of a small analyte ligand, leading to particle aggregation and then red-to-purple colour change of the colloidal solution.

Graphical abstract: A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex

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Publication details

The article was received on 25 Jan 2017, accepted on 27 Feb 2017 and first published on 28 Feb 2017


Article type: Communication
DOI: 10.1039/C7NR00612H
Citation: Nanoscale, 2017,9, 4048-4052
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    A colorimetric nanosensor based on a selective target-responsive aptamer kissing complex

    E. Goux, E. Dausse, V. Guieu, L. Azéma, G. Durand, M. Henry, L. Choisnard, J.-J. Toulmé, C. Ravelet and E. Peyrin, Nanoscale, 2017, 9, 4048
    DOI: 10.1039/C7NR00612H

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