Transformation from Single-Mesoporous to Dual-Mesoporous Organosilica Nanoparticles
Transformation from single-mesoporous to dual-mesoporous structured organosilica nanoparticles can be achieved by simply varying the volume fraction of ethanol in the synthesis system, using lauryl sulfonate betaine and sodium dodecyl sulfonate as dual-templates. Core-shell structured dual-mesoporous organosilica nanoparticles possess smaller mesopores (4.0 nm) in the shell and flower-like larger mesopores (46 nm) in the core. Owing to the unique mesostructure, dual-mesoporous organosilica nanoparticles show high loading capacity and slow release rate for cargo molecules. The inside large mesopores can provide large storage space for the guest molecules and small mesopores in the outer shell act as nature valve, slowing the release. In addition, both single-mesoporous and dual-mesoporous organosilica nanoparticles exhibit low cell toxicity and excellent cell permeability.