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Issue 12, 2017
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Encapsulation of aggregated gold nanoclusters in a metal–organic framework for real-time monitoring of drug release

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Abstract

Gold nanoclusters (AuNCs), which have stable luminescence and negligible biotoxicity, are a promising candidate in biological fields. However, their low photoluminescence (PL) efficiency is unsatisfactory. Herein, aggregated gold nanoclusters (aAuNCs) were confined in a metal–organic framework (MOF) to maintain their aggregation, restrict the rotation of their ligands, and further improve their quantum yield (QY) to 7.74%. The aAuNCs-MOF exhibited high luminescence and good biocompatibility. More importantly, in addition to its pH-dependent luminescence and external porosity, the complex was applied for the first time in real-time monitoring of drug release.

Graphical abstract: Encapsulation of aggregated gold nanoclusters in a metal–organic framework for real-time monitoring of drug release

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Publication details

The article was received on 04 Jan 2017, accepted on 15 Feb 2017 and first published on 16 Feb 2017


Article type: Paper
DOI: 10.1039/C7NR00073A
Citation: Nanoscale, 2017,9, 4128-4134
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    Encapsulation of aggregated gold nanoclusters in a metal–organic framework for real-time monitoring of drug release

    F. Cao, E. Ju, C. Liu, W. Li, Y. Zhang, K. Dong, Z. Liu, J. Ren and X. Qu, Nanoscale, 2017, 9, 4128
    DOI: 10.1039/C7NR00073A

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