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Issue 17, 2017
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Inducible epitope imprinting: ‘generating’ the required binding site in membrane receptors for targeted drug delivery

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Abstract

We report an inducible epitope imprinting strategy that as a template, a flexible peptide chain can have a disordered-to-ordered conformational change by suitable inducement through a molecular imprinting procedure, and the formed nanoparticles can, in turn, remold the original peptide into the expected conformation and specifically bind to the corresponding protein.

Graphical abstract: Inducible epitope imprinting: ‘generating’ the required binding site in membrane receptors for targeted drug delivery

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Publication details

The article was received on 06 Dec 2016, accepted on 29 Mar 2017 and first published on 07 Apr 2017


Article type: Communication
DOI: 10.1039/C6NR09449J
Citation: Nanoscale, 2017,9, 5394-5397
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    Inducible epitope imprinting: ‘generating’ the required binding site in membrane receptors for targeted drug delivery

    S. Liu, Q. Bi, Y. Long, Z. Li, S. Bhattacharyya and C. Li, Nanoscale, 2017, 9, 5394
    DOI: 10.1039/C6NR09449J

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