Jump to main content
Jump to site search

Issue 14, 2017
Previous Article Next Article

Multiple imaging and excellent anticancer efficiency of an upconverting nanocarrier mediated by single near infrared light

Author affiliations

Abstract

It is difficult to meet the requirements of clinical diagnosis through a single imaging technique. Similarly, satisfactory therapy efficacy is also hard to achieve by a single therapeutic modality. It is therefore highly desirable and interesting to simultaneously achieve multimodal imaging and therapies in one single structure. In this study, we developed a core–shell-satellite NaGdF4:Yb,Er,Mn,Co@mSiO2-CuS structure using up-conversion luminescent (UCL) NaGdF4:Yb,Er,Mn,Co as the core, mesoporous silica as the layer, and the photoactive CuS nanoparticles as the satellites. The further linked photosensitizer (ZnPc) and doxorubicin hydrochloride (DOX) allow the system to have photodynamic therapy (PDT) and chemotherapy functions. The doping of Co2+ ions in the core endows the carrier with T2-weighted magnetic resonance imaging (MRI) properties, and the co-doping of Mn2+ ions can efficiently enhance the red emission which further improves the PDT efficiency by reacting with the attached ZnPc upon near-infrared (NIR) light irradiation. The nanoplatform exhibits excellent anti-tumor efficiency due to a synergistic effect arising from combined PDT, photo-thermal therapy (PTT) and chemotherapy, which has been evidenced by in vitro and in vivo results. Due to the multimodal imaging (MRI, CT, and UCL) properties, the drug delivery process and therapeutic efficacy can be monitored in real time and assessed, thus achieving the target of imaging-guided therapy.

Graphical abstract: Multiple imaging and excellent anticancer efficiency of an upconverting nanocarrier mediated by single near infrared light

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 20 Nov 2016, accepted on 07 Mar 2017 and first published on 10 Mar 2017


Article type: Paper
DOI: 10.1039/C6NR09030C
Citation: Nanoscale, 2017,9, 4759-4769
  •   Request permissions

    Multiple imaging and excellent anticancer efficiency of an upconverting nanocarrier mediated by single near infrared light

    Y. Wang, G. Yang, Y. Wang, Y. Zhao, H. Jiang, Y. Han and P. Yang, Nanoscale, 2017, 9, 4759
    DOI: 10.1039/C6NR09030C

Search articles by author