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Issue 17, 2017
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Modular synthesis of supramolecular DNA amphiphiles through host–guest interactions and their self-assembly into DNA-decorated nanovesicles

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Abstract

DNA nanostructures have found potential applications in various fields including nanotechnology, materials science and nanomedicine, hence the design and synthesis of DNA nanostructures is extremely important. Self-assembly of DNA amphiphiles provides an efficient strategy for the crafting of soft DNA nanostructures. However, the synthesis of DNA amphiphiles is always challenging. Herein, we show a non-covalent approach based on the host–guest interaction between β-CD and adamantane for the synthesis of DNA amphiphiles, and report their amphiphilicity-driven self-assembly into DNA decorated vesicles. The DNA-directed surface addressability of the vesicles is demonstrated through their surface decoration with Au-NPs through DNA hybridization. Our results suggest that the non-covalent approach represents a simple, efficient and universal method for the synthesis of DNA amphiphiles, and provides an excellent strategy for the creation of smart DNA nanostructures.

Graphical abstract: Modular synthesis of supramolecular DNA amphiphiles through host–guest interactions and their self-assembly into DNA-decorated nanovesicles

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Publication details

The article was received on 27 Oct 2016, accepted on 06 Mar 2017 and first published on 09 Mar 2017


Article type: Paper
DOI: 10.1039/C6NR08370F
Citation: Nanoscale, 2017,9, 5425-5432
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    Modular synthesis of supramolecular DNA amphiphiles through host–guest interactions and their self-assembly into DNA-decorated nanovesicles

    S. K. Albert, H. V. P. Thelu, M. Golla, N. Krishnan and R. Varghese, Nanoscale, 2017, 9, 5425
    DOI: 10.1039/C6NR08370F

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