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Issue 16, 2017
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Gold nanotriangles: scale up and X-ray radiosensitization effects in mice

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Abstract

Abstract In the past decade, there has been considerable interest in radiosensitization using gold nanoparticles that accumulate specifically in cancerous tissue while sparing normal tissues. Despite this interest, it remains unclear which nanoparticle morphologies, cellular uptake, or cytoplasmic distribution elicit optimal radiosensitization. We introduce gold nanotriangles (AuNTs) as a possible X-ray radiotherapy sensitizer. In this study, we first explored a large-scale synthetic method for the production of high quality monodisperse AuNTs. Second, we conducted in vitro and in vivo experiments to evaluate the effect of PEGylated AuNTs (pAuNTs) on cellular uptake, cytotoxicity, bio-distribution, and radiosensitization on radiation-resistant human Glioblastoma Multiforme (GBM) cells. Our results suggest that the new scale up synthesis methodology consistently produced high quality AuNTs and pAuNTs which had nonspecific cellular uptake without any obvious cytotoxicity and exhibited excellent radiosensitization.

Graphical abstract: Gold nanotriangles: scale up and X-ray radiosensitization effects in mice

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Publication details

The article was received on 18 Oct 2016, accepted on 19 Jan 2017 and first published on 23 Jan 2017


Article type: Paper
DOI: 10.1039/C6NR08172J
Citation: Nanoscale, 2017,9, 5085-5093
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    Gold nanotriangles: scale up and X-ray radiosensitization effects in mice

    S. R. Bhattarai, P. J. Derry, K. Aziz, P. K. Singh, A. M. Khoo, A. S. Chadha, A. Liopo, E. R. Zubarev and S. Krishnan, Nanoscale, 2017, 9, 5085
    DOI: 10.1039/C6NR08172J

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