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Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes

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Abstract

Materials and methods aimed at the next generation of nanoscale carriers for drugs and other therapeutics are currently in great demand. Yet, creating these precise molecular arrangements in a feasible and straightforward manner represents a remarkable challenge. Herein we report a modular synthetic route for amphiphilic Janus-dendrimers via a copper-catalyzed click reaction (CuAAC) and a facile procedure, using simple injection, to obtain highly uniform dendrimersomes with efficient loading of the model drug compound propranolol. The resulting assemblies were analyzed by dynamic light scattering and cryogenic transmission electron microscopy revealing the formation of unilamellar and multilamellar dendrimersomes. The formation of a bilayer structure was confirmed using cryo-TEM and confocal microscopy visualization of an encapsulated solvatochromic dye (Nile Red). The dendrimersomes reported here are tunable in size, stable over time and display robust thermal stability in aqueous media. Our results expand the scope of dendrimer-based supramolecular colloidal systems and offer the means for one-step fabrication of drug-loaded dendrimersomes in the size range of 90–200 nm, ideal for biomedical applications.

Graphical abstract: Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes

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Publication details

The article was received on 15 Oct 2016, accepted on 03 May 2017 and first published on 08 May 2017


Article type: Paper
DOI: 10.1039/C6NR08102A
Citation: Nanoscale, 2017, Advance Article
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    Modular synthesis of self-assembling Janus-dendrimers and facile preparation of drug-loaded dendrimersomes

    S. Nummelin, M. Selin, S. Legrand, J. Ropponen, J. Seitsonen, A. Nykänen, J. Koivisto, J. Hirvonen, M. A. Kostiainen and L. M. Bimbo, Nanoscale, 2017, Advance Article , DOI: 10.1039/C6NR08102A

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