Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Expansion of chemical space for natural products by uncommon P450 reactions

Author affiliations

Abstract

Covering: 2000 to 2017

Cytochrome P450 enzymes (P450s) are the most versatile biocatalysts in nature. The catalytic competence of these extraordinary hemoproteins is broadly harnessed by numerous chemical defenders such as bacteria, fungi, and plants for the generation of diverse and complex natural products. Rather than the common tailoring reactions (e.g. hydroxylation and epoxidation) mediated by the majority of biosynthetic P450s, in this review, we will focus on the unusual P450 enzymes in relation to new chemistry, skeleton construction, and structure re-shaping via their own unique catalytic power or the intriguing protein–protein interactions between P450s and other proteins. These uncommon P450 reactions lead to a higher level of chemical space expansion for natural products, through which a broader spectrum of bioactivities can be gained by the host organisms.

Graphical abstract: Expansion of chemical space for natural products by uncommon P450 reactions

Back to tab navigation

Publication details

The article was received on 01 May 2017 and first published on 03 Aug 2017


Article type: Review Article
DOI: 10.1039/C7NP00028F
Citation: Nat. Prod. Rep., 2017,34, 1061-1089
  •   Request permissions

    Expansion of chemical space for natural products by uncommon P450 reactions

    X. Zhang and S. Li, Nat. Prod. Rep., 2017, 34, 1061
    DOI: 10.1039/C7NP00028F

Search articles by author

Spotlight

Advertisements