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Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes

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Abstract

Covering: 2001 up to the end of 2016

Polyphenols comprise a structurally diverse class of natural products. As the development of new anthelmintic drugs against soil-transmitted helminthiases is an urgent need and polyphenols are widely used in the treatment of nematode infections in traditional medicine and modern science, we summarize the state of knowledge in the period of mainly 2001 up to the end of 2016 on plant extracts with known polyphenolic composition and of defined polyphenols, mainly from the classes of condensed and hydrolysable tannins, flavonoids, and phenylpropanoids. The diverse biological activity against different helminths and the underlying mechanisms are reviewed.

Graphical abstract: Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes

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Publication details

The article was received on 28 Dec 2016 and first published on 20 Apr 2017


Article type: Review Article
DOI: 10.1039/C6NP00126B
Citation: Nat. Prod. Rep., 2017, Advance Article
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    Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes

    V. Spiegler, E. Liebau and A. Hensel, Nat. Prod. Rep., 2017, Advance Article , DOI: 10.1039/C6NP00126B

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