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Issue 4, 2017
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Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids

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Abstract

Covering: 2000 to 2017

Ergot alkaloids are among the most important pharmaceuticals and natural toxins. Significant progress has been achieved in recent years on the research of ergot alkaloids. In this review, we re-introduced the history of ergot alkaloids. Meanwhile, we summarized all the natural products and semi-synthetic derivatives of ergot alkaloids. We also briefly described the biosynthesis and semi-synthesis of ergot alkaloid drugs from raw materials obtained by fermentation. Moreover, we reviewed the advances that have been made in the total synthesis of ergot alkaloids since 2000.

Graphical abstract: Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids

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Publication details

The article was received on 30 Oct 2016 and first published on 16 Mar 2017


Article type: Review Article
DOI: 10.1039/C6NP00110F
Citation: Nat. Prod. Rep., 2017,34, 411-432
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    Ergot alkaloids: synthetic approaches to lysergic acid and clavine alkaloids

    H. Liu and Y. Jia, Nat. Prod. Rep., 2017, 34, 411
    DOI: 10.1039/C6NP00110F

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