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Cycloplatinated(II) complexes bearing 1,1'-bis(diphenylphosphino)ferrocene ligand: Biological evaluation and molecular docking studies

Abstract

In this study, the cytotoxic activities of structurally related cycloplatinated(II) complexes containing chelating and bridging 1,1'-bis(diphenylphosphino)ferrocene (dppf) ligand derived from a wide range of C^N cyclometalating ligands (vpy = deprotonated 2-vinylpyridine, bzq = deprotonated benzo[h]quinoline, bpy = deprotonated 2,2'-bipyridine, bpyO = deprotonated 2,2'-bipyridine N-oxide, ppy = deprotonated 2-phenylpyridine), were evaluated against human lung (A549), ovarian (SKOV3) and breast (MCF-7) cancer cell lines. The most cytotoxic compounds, i.e. 2a, 2c and 2d, effectively produce cell death by inducing apoptosis in A549, SKOV3 and MCF-7 cancer cell lines. In addition, the molecular docking simulation were performed to determine the specific binding mode and the orientation of binding to DNA. According to the result of biological evaluation, the dppf-containing cycloplatinated(II) complexes exhibited strong interactions with DNA, high cytotoxicity and apoptosis-inducing activities to human cancer cell line. The present work suggests that precise rational design of new platinum-based complexes would result in the preparation of potentially anticancer drugs which can induce facile apoptosis.

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Publication details

The article was received on 29 Oct 2017, accepted on 05 Dec 2017 and first published on 05 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ04183G
Citation: New J. Chem., 2017, Accepted Manuscript
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    Cycloplatinated(II) complexes bearing 1,1'-bis(diphenylphosphino)ferrocene ligand: Biological evaluation and molecular docking studies

    M. fereidoonnezhad, H. R. Shahsavari, S. abedanzadeh, B. Behchenari, M. Hossein-Abadi, Z. Faghih and M. H. Beyzavi, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ04183G

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