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Issue 24, 2017
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Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

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Abstract

7-Dehydrocholesterol peroxide (5α,8α-epidioxycholest-6-ene-3β-ol, CEP) and its acetate and hemisuccinate derivatives were synthesized and isolated for the first time, which exhibit improved anticancer activity and selectivity over ergosterol peroxide (5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol, EEP), showing potential as new chemotherapeutic agents.

Graphical abstract: Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

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Publication details

The article was received on 23 Oct 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017


Article type: Letter
DOI: 10.1039/C7NJ04100D
Citation: New J. Chem., 2017,41, 14843-14846
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    Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

    N. Tian, C. Li, N. Tian, Q. Zhou, Y. Hou, B. Zhang and X. Wang, New J. Chem., 2017, 41, 14843
    DOI: 10.1039/C7NJ04100D

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