Jump to main content
Jump to site search


Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

Author affiliations

Abstract

7-Dehydrocholesterol peroxide (5α,8α-epidioxycholest-6-ene-3β-ol, CEP) and its acetate and hemisuccinate derivatives were synthesized and isolated for the first time, which exhibit improved anticancer activity and selectivity over ergosterol peroxide (5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol, EEP), showing potential as new chemotherapeutic agents.

Graphical abstract: Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Oct 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017


Article type: Letter
DOI: 10.1039/C7NJ04100D
Citation: New J. Chem., 2017, Advance Article
  •   Request permissions

    Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

    N. Tian, C. Li, N. Tian, Q. Zhou, Y. Hou, B. Zhang and X. Wang, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ04100D

Search articles by author

Spotlight

Advertisements