Issue 24, 2017
From the journal:

New Journal of Chemistry

Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide†

Na-na Tian,ab   Chao Li,*a   Na Tian,ab   Qian-xiong Zhou,a   Yuan-jun Hou,a   Bao-wen Zhanga  and  Xue-song Wang ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, lychaof@mail.ipc.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

7-Dehydrocholesterol peroxide (5α,8α-epidioxycholest-6-ene-3β-ol, CEP) and its acetate and hemisuccinate derivatives were synthesized and isolated for the first time, which exhibit improved anticancer activity and selectivity over ergosterol peroxide (5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol, EEP), showing potential as new chemotherapeutic agents.

Graphical abstract: Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

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Article information

DOI
https://doi.org/10.1039/C7NJ04100D
Article type
Letter
Submitted
23 Oct 2017
Accepted
11 Nov 2017
First published
13 Nov 2017

New J. Chem., 2017,41, 14843-14846

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Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

N. Tian, C. Li, N. Tian, Q. Zhou, Y. Hou, B. Zhang and X. Wang, New J. Chem., 2017, 41, 14843 DOI: 10.1039/C7NJ04100D

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