Jump to main content
Jump to site search


Rapid synthesis of carbonucleoside phophonate analogues as potential antiviral agents via a hydrophosphonylation reaction of ethynyl carbocyclic precursors

Author affiliations

Abstract

A racemic synthesis of new carbocyclic nucleoside ethyl or vinylphosphonate analogues bearing purine bases (adenine and guanine) was accomplished using racemic (+/−)-4-O-protected-2-cyclopentanone. All compounds were prepared using a hydrophosphonylation reaction of ethynyl carbocyclic precursors followed by a Mitsunobu coupling reaction between the heterocyclic bases. After deprotection, the compounds were evaluated for their activity against a large number of viruses. However, none of them showed significant antiviral activity or cytotoxicity.

Graphical abstract: Rapid synthesis of carbonucleoside phophonate analogues as potential antiviral agents via a hydrophosphonylation reaction of ethynyl carbocyclic precursors

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Oct 2017, accepted on 06 Dec 2017 and first published on 06 Dec 2017


Article type: Paper
DOI: 10.1039/C7NJ03991C
Citation: New J. Chem., 2018, Advance Article
  •   Request permissions

    Rapid synthesis of carbonucleoside phophonate analogues as potential antiviral agents via a hydrophosphonylation reaction of ethynyl carbocyclic precursors

    B. Sidi Mohamed, C. Périgaud, S. Peyrottes, J. Uttaro and C. Mathé, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03991C

Search articles by author

Spotlight

Advertisements