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Studies on Drug Release Kinetics and Antibacterial activity against Drug-resistant Bacteria of Cefotaxime Sodium Loaded Layered Double Hydroxide–Fenugreek Nanohybrid

Abstract

In the current work, we report the loading of cefotaxime sodium on Mg-Al layered double hydroxide (Cefo-LDH) and formation of nanohybrid with fenugreek polymer (CLF nanohybrid). These nanohybrids were synthesized through the method of anion-exchange followed by sonication. The as-synthesized CLF nanohybrid was thoroughly characterized by XRD, FTIR and zeta potential measurements, which reveal that the cefotaxime drug is bound to LDH surface. The drug loading capacity of Cefo-LDH and CLF nanohybrid was found to be 85.6 and 72.5 µg/mg respectively. The drug released from CLF nanohybrid demonstrates a controlled and sustained profile at pH 7.3 over a period of 72 h. The mechanism of drug release is explained by the first-order and parabolic kinetic models. The kinetic models suggest that the release of cefotaxime is dependent upon the dissolution and diffusion of drug molecules in the physiological medium. At a concentration up to 1 mg/mL, both Cefo-LDH and CLF nanohybrid are seen to be biocompatible with murine fibroblast (L929) cells. Further, antibacterial activity studies, against cefotaxime drug-resistant Escherichia coli (E. coli) strain, show about 98% of cell mortality with 1 mg/mL of nanohybrid loaded with cefotaxime.

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Publication details

The article was received on 21 Sep 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03622A
Citation: New J. Chem., 2017, Accepted Manuscript
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    Studies on Drug Release Kinetics and Antibacterial activity against Drug-resistant Bacteria of Cefotaxime Sodium Loaded Layered Double Hydroxide–Fenugreek Nanohybrid

    E. V. R. K, S. Doshi, S. Thiyagarajan, M. Aslam and D. Bahadur, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ03622A

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