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A designed synthesis of multifunctional carbon nanoframes for simultaneous imaging and synergistic chemo-photothermal cancer therapy

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Abstract

Owing to their small size and unique optical properties, carbon nanomaterials have attracted considerable attention due to their promising biomedical applications. In this work, we report a silica (SiO2) protected calcination strategy to fabricate mesoporous carbon nanoframes (mCNFs) from zeolitic imidazolate framework-8 (ZIF-8) precursors. The resulting mCNFs have many merits including drug loading capability, excellent photothermal efficiency (21%), dual pH/near-infrared (NIR) responsive controlled drug release and good biocompatibility. When 5-FU-loaded mCNFs were subjected to NIR irradiation, a burst release of 5-FU occurs owing to the heat produced by the mCNFs. Furthermore, mCNFs are successfully employed for photoacoustic imaging (PAI) and synergistic chemo-photothermal cancer therapy. Taken together, mCNFs can be developed as a promising theranostic agent for cancer treatment.

Graphical abstract: A designed synthesis of multifunctional carbon nanoframes for simultaneous imaging and synergistic chemo-photothermal cancer therapy

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Publication details

The article was received on 20 Sep 2017, accepted on 22 Nov 2017 and first published on 23 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03598E
Citation: New J. Chem., 2018, Advance Article
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    A designed synthesis of multifunctional carbon nanoframes for simultaneous imaging and synergistic chemo-photothermal cancer therapy

    X. Wei, L. Zhang, S. Li, X. Chen, M. Zhang, C. Wang, T. Wang and L. Li, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03598E

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