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Magnetically recoverable graphene-based nanocomposite material as an efficient catalyst for the synthesis of propargylamines via A3 coupling reaction

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Abstract

The magnetically separable Au NPs–Fe3O4–rGO catalyst provides a robust and efficient route for the A3 coupling reaction of secondary amines, terminal alkynes and aldehyde with tolerance of diverse functional groups for the synthesis of propargylamine in high yields. Further, the catalyst could be reused several times without losing significant activity due to the stability of the NPs onto reduced graphene oxide sheets (rGO). The synthesized catalyst was characterized by different instrumental techniques before as well as after the catalytic reaction and it was observed that the catalyst retained its size and surface morphology after the reaction. The advantages of using the Au NPs–Fe3O4–rGO catalyst for the synthesis of pharmaceutically important compounds, propargylamines, over those in previous reports include its magnetically separable nature, additive-free characteristic, functional group tolerance and recyclability. The enhanced catalytic activity of the Au NPs–Fe3O4–rGO composite material results from the synergistic effect among Au NPs, Fe3O4 NPs and rGO sheets.

Graphical abstract: Magnetically recoverable graphene-based nanocomposite material as an efficient catalyst for the synthesis of propargylamines via A3 coupling reaction

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Publication details

The article was received on 08 Sep 2017, accepted on 20 Sep 2017 and first published on 21 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ03412A
Citation: New J. Chem., 2017, Advance Article
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    Magnetically recoverable graphene-based nanocomposite material as an efficient catalyst for the synthesis of propargylamines via A3 coupling reaction

    N. Hussain and M. R. Das, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ03412A

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