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Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates

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Abstract

A friendly protocol is reported to achieve cyanation of aromatic and vinylic boronic acids using nontoxic and readily available α-cyanoacetates as a cyano source under aerobic conditions. Many aryl/vinyl boronic acids (as well as some iodides and bromides) are amenable substrates to give aryl nitriles and acrylonitriles. This cyanation method provides a safe and operationally convenient alternative to traditional ones requiring toxic cyanide salts.

Graphical abstract: Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates

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Publication details

The article was received on 08 Sep 2017, accepted on 31 Oct 2017 and first published on 01 Nov 2017


Article type: Letter
DOI: 10.1039/C7NJ03405A
Citation: New J. Chem., 2017, Advance Article
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    Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates

    X. Wang and S. Zhang, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ03405A

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