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An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

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Abstract

A convenient one-pot protocol was developed for the synthesis of spiro[indeno[2,1-c]pyridazine-9,4′-pyran]-3′,4-dicarbonitrile derivatives by the reaction of cyanoacetohydrazide, ninhydrin, malononitrile and various cyclic CH-acids under reflux condition in ethanol. No hazardous solvent or catalyst was used in this method. The main advantages of this procedure are the availability of starting materials, very high yields and easy purification.

Graphical abstract: An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

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Publication details

The article was received on 07 Sep 2017, accepted on 01 Nov 2017 and first published on 10 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03397D
Citation: New J. Chem., 2017, Advance Article
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    An efficient synthesis of novel spiroindenopyridazine-4H-pyran derivatives

    M. Bayat and H. Hosseini, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ03397D

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