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Issue 23, 2017
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Photo-induced synthesis and in vitro antitumor activity of Fenestin A analogs

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Abstract

Two novel Fenestin A analogs (1 and 2) containing a phthalimide moiety are prepared by photoinduced cyclization. Their absolute configurations were determined by experimental ECD with the aid of theoretical calculations. The resulting compounds are active in HeLa (IC50 = 28.2 μM for 1 and 36.5 μM for 2) and HepG-2 cell lines (IC50 = 33.5 μM for 1 and 40.3 μM for 2).

Graphical abstract: Photo-induced synthesis and in vitro antitumor activity of Fenestin A analogs

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Publication details

The article was received on 05 Sep 2017, accepted on 13 Oct 2017 and first published on 16 Oct 2017


Article type: Letter
DOI: 10.1039/C7NJ03363J
Citation: New J. Chem., 2017,41, 14044-14048
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    Photo-induced synthesis and in vitro antitumor activity of Fenestin A analogs

    L. Zhao, H. Zhang, J. Cui, M. Zhao, Z. Wang, Q. Yue and Y. Jin, New J. Chem., 2017, 41, 14044
    DOI: 10.1039/C7NJ03363J

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