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Fucoidan coated core-shell magnetic mesoporous silica nanoparticles for chemotherapy and magnetic hyperthermia-based thermal therapy applications

Abstract

Core-shell based, bioactive marine biopolymer-coated drug carriers for high drug loading and efficient drug release response to a specific trigger receives much research interest in cancer therapy. In this study, we present a fucoidan coated core-shell magnetic mesoporous silica drug carrier (FeNP@SiOH@Fuc NPs) system which, consisting of a magnetic iron oxide (FeNP) core, a mesoporous silica shell (SiOH), and a marine biopolymer, namely fucoidan (Fuc), were coated onto the outer surface as a “gatekeeper” for pH-responsive drug delivery and magnetic hyperthermia applications. The fucoidan coating onto the outer surface of the silica nanoparticles was performed through metal-ligand complex coordination approaches. The drug loaded FeNP@SiOH@Fuc/Dox NPs show good drug retention efficiency under a physiological pH condition and shows a pHresponsive drug release behavior under an acidic pH environment and hyperthermia temperature (45 °C) conditions in the presence of an alternating magnetic field (AMF). Furthermore, the MTT assay and the intracellular uptake study results indicate that the synthesized FeNP@SiOH@Fuc NPs has biocompatibility and could be efficiently internalized by MDA-MB- 231 cells. In addition, owing to the presence of a magnetic iron oxide core, the FeNP@SiOH@Fuc NPs show an excellent magnetic hyperthermia heating efficiency in the presence of AMF and reach the hyperthermia temperature (45 °C) within a very short time (approximately ~4-5 min). Since the FeNP@SiOH@Fuc NPs system exhibits the pH-stimuli responsive drug release performance, good biocompatibility, and efficient magnetic hyperthermia heating efficiency, the proposed system is expected to be a promising candidate as a drug carrier as well as a hyperthermia agent for chemotherapy and magnetic hyperthermia-based thermal therapy applications in emerging cancer therapy.

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Publication details

The article was received on 25 Aug 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03211K
Citation: New J. Chem., 2017, Accepted Manuscript
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    Fucoidan coated core-shell magnetic mesoporous silica nanoparticles for chemotherapy and magnetic hyperthermia-based thermal therapy applications

    J. Oh, M. Santha Moorthy, B. Subramaniyan, M. Panchanathan, S. Mondal, H. Kim and K. D. Lee, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ03211K

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