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Highly selective and sensitive biosensing of dopamine based on glutathione coated silver nanoclusters enhanced fluorescence

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Abstract

This study describes an ultrasensitive and highly selective dopamine (DA) assay that makes use of glutathione protected silver nanoclusters (GSH-AgNCs) acting as a nanoprobe. The GSH-AgNCs exhibit red fluorescence (with excitation/emission peaks at 490/645 nm), which increases on addition of DA, probably due to the hydrogen bonding interaction of the carboxyl groups of GSH-AgNCs and the amino groups of DA. The response is linear in the 20 × 10−9 mol dm−3 to 220 × 10−9 mol dm−3 DA concentration range, and the lowest limit of detection is 0.35 × 10−9 mol dm−3 (at an S/N ratio of 3). Potential interferents including uric acid, ascorbic acid, common metal ions, anions and some biologically relevant chemicals do not have an effect even in 100-fold higher concentrations. Furthermore, the present analytical assay was effectively utilized for the quantification of DA in spiked human urine samples.

Graphical abstract: Highly selective and sensitive biosensing of dopamine based on glutathione coated silver nanoclusters enhanced fluorescence

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Publication details

The article was received on 23 Aug 2017, accepted on 27 Oct 2017 and first published on 01 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03170J
Citation: New J. Chem., 2017, Advance Article
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    Highly selective and sensitive biosensing of dopamine based on glutathione coated silver nanoclusters enhanced fluorescence

    R. Rajamanikandan and M. Ilanchelian, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ03170J

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