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Development of self-repair Nano-rod scaffold materials for Implantation of Osteosarcoma affected Bone Tissue

Abstract

Osteosarcoma is the most widely recognized fatal bone disease in children and young adult people. The Osteosarcoma affected places of bone implant materials lose their activity after some periods due to the possibility of regenerate sarcoma cells. Hence, the complete recovery of this disease is very challenging one. Subsequently, new helpful methodologies, natural antioxidant loaded bone implant materials are effectively treated Osteosarcoma cells. In this regards, the nano-hydroxyapatite reinforced with xylitol based poly (xylitol sebacate) PXS co-polymer with capsaicin loaded scaffold was investigated on Osteosarcoma cells. The physicochemical properties of the scaffold were evaluated through FT-IR (Fourier transforms infrared spectroscopy), SEM (Scanning electron microscopy), TEM (Transmission electron microscopy), and XRD (X-ray diffraction analysis). The In-vitro release and antioxidant activity of capsaicin loaded nHAP/PXS/CAP scaffold were evaluated by UV-Visible spectroscopy analysis. Their cytotoxicity against the Saos-2 Cancer line and cell viability in Osteoblasts cell MG63 are reported. Eventually, the composite enlarges the creation of reactive oxygen species (ROS) in Saos-2 cells.

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Publication details

The article was received on 22 Aug 2017, accepted on 14 Nov 2017 and first published on 14 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03143B
Citation: New J. Chem., 2017, Accepted Manuscript
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    Development of self-repair Nano-rod scaffold materials for Implantation of Osteosarcoma affected Bone Tissue

    M. Rajan, S. murugan, S. A. Alyahya, N. S. Alharbi, S. Kadaikunnan and S. S. Kumar, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ03143B

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