Jump to main content
Jump to site search


Oxidative amidation of benzaldehydes and benzylamines with N-substituted formamides over a Co/Al hydrotalcite-derived catalyst

Author affiliations

Abstract

The present work describes a highly efficient synthetic strategy for amides via oxidative coupling of benzaldehydes or benzylamines with N-substituted formamides using a heterogeneous Co/Al hydrotalcite-derived catalyst in the presence of TBHP. A series of Co/Al hydrotalcite-derived catalysts (Cat-2, Cat-3, and Cat-4 with the Co2+/Al3+ molar ratio in the synthesis mixture as 1/1, 2/1 and 3/1) have been prepared by a simple co-precipitation method and characterized using powder XRD, XPS, FEG-SEM, EDS, FT-IR, DTG-TGA and N2 physical adsorption techniques. Among the as-prepared catalysts, Cat-3 exhibited excellent catalytic activity towards the direct amidation of benzaldehydes as well as benzylamines bearing various substituents into the corresponding amides at 100 °C using TBHP as an oxidant. The mechanistic investigation of the amidation reaction revealed that the reaction follows a radical pathway. Furthermore, the catalyst is easily separable and recyclable without considerable loss in catalytic activity.

Graphical abstract: Oxidative amidation of benzaldehydes and benzylamines with N-substituted formamides over a Co/Al hydrotalcite-derived catalyst

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Aug 2017, accepted on 06 Nov 2017 and first published on 07 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03123H
Citation: New J. Chem., 2017, Advance Article
  •   Request permissions

    Oxidative amidation of benzaldehydes and benzylamines with N-substituted formamides over a Co/Al hydrotalcite-derived catalyst

    S. S. R. Gupta, A. V. Nakhate, K. B. Rasal, G. P. Deshmukh and L. K. Mannepalli, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ03123H

Search articles by author

Spotlight

Advertisements