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Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA-drug conjugates

Abstract

Herein, a method for the synthesis of PLA-(β-blocker) conjugates with tunable stereostructure of PLA fragment is demonstrated using stereoselective [R2Ga(μ-β-blocker)]2 catalysts and [R2Ga(μ-OR)]2/H-(β-blocker) catalytic systems for the ring-opening polymerisation (ROP) and immortal ring-opening polymerisation (iROP) of racemic lactide (rac-LA), respectively.

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Publication details

The article was received on 18 Aug 2017, accepted on 09 Nov 2017 and first published on 10 Nov 2017


Article type: Letter
DOI: 10.1039/C7NJ03089D
Citation: New J. Chem., 2017, Accepted Manuscript
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    Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA-drug conjugates

    M. Cybularczyk, R. Zaremba, A. Hurko, A. T. Plichta, M. Dranka and P. Horeglad, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ03089D

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