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Photoredox catalysed synthesis of amino alcohol

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Abstract

A mild and efficient one-pot visible light-induced method has been developed for the synthesis of amino alcohols. Amino alcohols are important structural elements that are frequently found in pharmaceutical agents and biologically active natural products. The routine procedure in the drug discovery and development process to prepare and fully characterize amino alcohols makes them a drug candidate for biological evaluation. This protocol utilizes visible light as the greenest reagent and eosin Y as an organophotoredox catalyst to synthesise bioactive amino alcohols. Gram scale reactions demonstrated the potential synthetic applications of this protocol.

Graphical abstract: Photoredox catalysed synthesis of amino alcohol

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Publication details

The article was received on 17 Aug 2017, accepted on 26 Nov 2017 and first published on 29 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03068A
Citation: New J. Chem., 2018, Advance Article
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    Photoredox catalysed synthesis of amino alcohol

    V. Srivastava, P. K. Singh, S. Kanaujia and P. P. Singh, New J. Chem., 2018, Advance Article , DOI: 10.1039/C7NJ03068A

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