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Electrochemical sensor for the simultaneous determination of rifampicin and isoniazid using a C-dots@CuFe2O4 nanocomposite modified carbon paste electrode

Abstract

In this study, a sensitive carbon paste electrode based on a novel nanocomposite of carbon dots /CuFe2O4 (C-dots@ CuFe2O4) was developed for the simultaneous determination of rifampicin (RIF) and isoniazid (INZ). The morphological and structural properties of the C-dots@CuFe2O4 were well cracterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Under optimized conditions, the voltammetric current has increased linearly with increasing the concentration of RIF and INZ in the range of 0.07 to 8.0 and 0.1 to 14.0 µmol L-1, respectively. Moreover, the detection limits for the analytes were calculated 0.022 µmol L-1 for RIF and 0.041 µmol L-1 for INZ based on 3Sb/m. The practical applicability of the proposed sensor was examined by evaluating the detection of RIF and INZ in biological fluids and pharmaceutical samples with satisfied recoveries. The C-dots@CuFe2O4/CPE can hold great promise for fast, simple and sensitive detection of RIF and INZ in various real samples.

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Publication details

The article was received on 14 Aug 2017, accepted on 03 Nov 2017 and first published on 10 Nov 2017


Article type: Paper
DOI: 10.1039/C7NJ03029K
Citation: New J. Chem., 2017, Accepted Manuscript
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    Electrochemical sensor for the simultaneous determination of rifampicin and isoniazid using a C-dots@CuFe2O4 nanocomposite modified carbon paste electrode

    S. Shiri, N. Pajooheshpour, S. Amidi, H. Khoshsafar and H. Bagheri, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ03029K

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