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Preparation of Hollow Mesoporous Silica Nanospheres: Controllable Template Synthesis and their Application in Drug Delivery

Abstract

Hollow mesoporous silica nanospheres were prepared using different types of templates such as iron oxide nanoparticles (magnetite and hematite) and polymer nanospheres (polystyrene and resorcinol formaldehyde resin). The process involves a first step of coating silica on templates along with surfactants and then removal of both templates and surfactants to produce hollow mesoporous silica nanospheres in the second step. Characterization techniques, such as TEM, XRD, FTIR, TGA, and N2-adsorption-desorption analysis were used to characterize the samples and indicated the hollow and mesoporous structure of silica nanospheres. Ibuprofen as a drug model was used to investigate the drug adsorption behavior of the silica nanospheres which also showed sustained release property.

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Publication details

The article was received on 30 Jul 2017, accepted on 26 Sep 2017 and first published on 27 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ02804K
Citation: New J. Chem., 2017, Accepted Manuscript
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    Preparation of Hollow Mesoporous Silica Nanospheres: Controllable Template Synthesis and their Application in Drug Delivery

    Z. U. Rahman, N. Wei, Z. Li, W. Sun and D. Wang, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02804K

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