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Polymer decorated thiazole-functionalized magnetic particles for selective recognition and separation of hemoglobin

Abstract

In this study, a novel route was presented to fabricate magnetic polymeric microspheres to build a functional and convenient material for the separation of hemoglobin using distillation precipitation polymerization. The thiazolium-modified poly 4-vinylbenzylchloride (pVBC) shell was successfully grafted onto the surface of magnetic microspheres. The morphology, structure and composition of the materials were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. The experiment results showed that the as-synthesized Fe3O4@SiO2@pVBC@Thiaz magnetic microspheres showed a strong magnetic response to a remarkable adsorption capacity (5.03 mg/mg) via high thiazoliumion loading amount, and excellent specificity based on the covalent coordination between the iron ion in heme group of hemoglobin and the thiazolium. These results demonstrated that the microspheres had potential use in the separation of hemoglobin.

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Publication details

The article was received on 30 Jul 2017, accepted on 01 Oct 2017 and first published on 02 Oct 2017


Article type: Paper
DOI: 10.1039/C7NJ02801F
Citation: New J. Chem., 2017, Accepted Manuscript
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    Polymer decorated thiazole-functionalized magnetic particles for selective recognition and separation of hemoglobin

    Q. Li, B. Wang, J. Wang, X. Xi, Q. Chu, G. Dong and Y. Wei, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02801F

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