Jump to main content
Jump to site search

Issue 24, 2017
Previous Article Next Article

Applications of Keck allylation in the synthesis of natural products

Author affiliations

Abstract

This review highlights the applications of the Keck allylation reaction in the synthesis of medicinally important natural products. Keck allylation is a versatile chemical reaction used for the conversion of a variety of aldehydes into homoallylic alcohols and has many applications in the synthesis of biologically active natural products. Efforts have been made to comprehensively provide an overview of the role of the Keck allylation reaction in the synthesis of natural products including the synthesis of macrolides, phorboxazole B, mandelalide A, rhizopodin, palmerolide A, belactosin A and hormaomycin, bryostatin I, the anti-tumor drug epothilones B, and the anti-obesity drug orlistat. This review will be beneficial for the biological and synthetic communities.

Graphical abstract: Applications of Keck allylation in the synthesis of natural products

Back to tab navigation

Publication details

The article was received on 30 Jul 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Perspective
DOI: 10.1039/C7NJ02799K
Citation: New J. Chem., 2017,41, 14804-14821
  •   Request permissions

    Applications of Keck allylation in the synthesis of natural products

    T. Abdul Fattah and A. Saeed, New J. Chem., 2017, 41, 14804
    DOI: 10.1039/C7NJ02799K

Search articles by author

Spotlight

Advertisements