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Applications of Keck allylation in the synthesis of natural products

Abstract

This review highlights the applications of Keck allylation reaction in the synthesis of medicinally important natural products. Keck allyation is a versatile chemical reaction for the conversion of aldehydes into homoallylic alcohols and has many applications to the synthesis of biologically active natural products. An effort has been carried out to comprehensively provide an overview of the role of Keck allylation reaction in natural products synthesis, including synthesis of macrolides, phorboxazole B, mandelalide A, rhizopodin, palmerolide A, belactosin A and hormaomycin, bryostatin 1, antitumor drug epothilones B, and anti-obesity drug Orlistat. This review will be beneficial for both the biological and synthetic communities.

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Publication details

The article was received on 30 Jul 2017, accepted on 08 Nov 2017 and first published on 09 Nov 2017


Article type: Perspective
DOI: 10.1039/C7NJ02799K
Citation: New J. Chem., 2017, Accepted Manuscript
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    Applications of Keck allylation in the synthesis of natural products

    T. Abdul Fattah and A. Saeed, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02799K

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