Jump to main content
Jump to site search


Combining vitamin B12 to cisplatin-loaded porous silica nanoparticles via coordination: A facile approach to prepare targeted drug delivery system

Abstract

In this work, a novel drug delivery system for targeted therapy is developed based on noncovalent interactions. The strategy is to combine an active targeting unit and a passive targeting moiety via simple dative bonds. The system is composed of carboxyl group-modified porous silica nanoparticles (PSNs-C) as a drug carrier, cisplatin (CDDP) as an anticancer drug, and vitamin B12 (B12) as an active targeting unit for tumor cells. PSNs-C were prepared by co-condensation of TEOS and carboxyethylsilane (CES) using CTAB as the porous template. B12 was then successfully decorated onto the drug-loaded particles via coordination to the cobalt center. The obtained particles were characterized by XRD, FT-IR, UV-vis, SEM and DLS. The particles were spherical and monodisperse with an average diameter of 316±6 nm. In addition, B12 could control the drug release by serving as a gatekeeper to hinder the drug leaching during circulation. Under a reducing environment at pH 5.5, the cobalt center in B12 was reduced and cleaved from the particles which resulted in a significant enhancement of CDDP release.

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2017, accepted on 04 Oct 2017 and first published on 06 Oct 2017


Article type: Paper
DOI: 10.1039/C7NJ02754K
Citation: New J. Chem., 2017, Accepted Manuscript
  •   Request permissions

    Combining vitamin B12 to cisplatin-loaded porous silica nanoparticles via coordination: A facile approach to prepare targeted drug delivery system

    N. Thepphankulngarm, P. Wonganan, C. Sapcharoenkun, T. Tuntulani and P. Leeladee, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02754K

Search articles by author

Spotlight

Advertisements