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Drug delivery via anion exchange of salicylate decorating poly(meth)acrylates based on a pharmaceutical ionic liquid

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Abstract

Amphiphilic polymer carriers were designed for the delivery of ionically bonded drugs. The ionic liquid, trimethylammonium methacrylate monomer, containing biologically active salicylate anions was selected for the preparation of copolymers via atom transfer radical polymerization (ATRP) with methyl methacrylate (MMA) or methyl acrylate (MA). The resulting polymers varied in the content and arrangement of ionic units in the chain. The self-assembly of polymers in aqueous solution yielded particles at critical micelle concentration (CMC) values below 0.1 mg ml−1 and with hydrodynamic diameters in the range of 170–290 nm, which were also visualized by TEM. Drug release studies indicated the exchange of 42–52% of salicylate anions with phosphate anions using dialysis in PBS, which corresponded to 0.15–0.25 mg of salicylate released from 1 mg of polymeric carrier.

Graphical abstract: Drug delivery via anion exchange of salicylate decorating poly(meth)acrylates based on a pharmaceutical ionic liquid

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Publication details

The article was received on 21 Jul 2017, accepted on 21 Sep 2017 and first published on 22 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ02667F
Citation: New J. Chem., 2017, Advance Article
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    Drug delivery via anion exchange of salicylate decorating poly(meth)acrylates based on a pharmaceutical ionic liquid

    R. Bielas, D. Łukowiec and D. Neugebauer, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ02667F

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