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Copper-catalyzed aerobic oxidative intramolecular amidation of 2-aminophenylacetylenes: A domino process for the synthesis of isatin

Abstract

A novel CuI-catalyzed oxidative amidation of 2-aminophenylacetylenes leading to the formation of isatins by using open air as an oxygen source has been developed. The reaction proceeded smoothly and provided a variety of isatin derivatives in good yields. The advantages of this one-pot reaction protocol include green oxidant, low-price catalyst, facile conditions and easy handling.

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Publication details

The article was received on 06 Jul 2017, accepted on 11 Oct 2017 and first published on 12 Oct 2017


Article type: Paper
DOI: 10.1039/C7NJ02441J
Citation: New J. Chem., 2017, Accepted Manuscript
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    Copper-catalyzed aerobic oxidative intramolecular amidation of 2-aminophenylacetylenes: A domino process for the synthesis of isatin

    B. Das, N. Salvanna, P. Ramesh and K. Santosh Kumar, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02441J

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