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A green and efficient method for the synthesis of pyrroles using a deep eutectic solvent ([CholineCl][ZnCl2]3) under solvent-free sonication.

Abstract

An efficient deep eutectic solvent-based synthesis of pyrroles under ultrasound irradiation has been developed to provide a significant improvement of the yield up to 99% in a short reaction time. The synthesis of pyrroles is highly atom-economical, producing water as the sole byproduct. In addition, [CholineCl][ZnCl2]3 is easily synthesized from commercially available choline chloride and zinc chloride via a cost-effective and environmentally benign pathway. The obtained [CholineCl][ZnCl2]3 has been characterized by FT-IR, 1H-NMR, 13C-NMR, HRMS (ESI), Raman and TGA. Five new pyrroles are synthesized by the current method. Moreover, [CholineCl][ZnCl2]3 could be reused up to four times without significant loss of catalytic activity.

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Publication details

The article was received on 04 Jul 2017, accepted on 11 Sep 2017 and first published on 12 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ02396K
Citation: New J. Chem., 2017, Accepted Manuscript
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    A green and efficient method for the synthesis of pyrroles using a deep eutectic solvent ([CholineCl][ZnCl2]3) under solvent-free sonication.

    P. H. Tran, H. T. Nguyen and D. N. Chau, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02396K

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