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A Novel Sandwich-type Immunosensor Based on Three Dimensional Graphene-Au Aerogels and Quaternary Chalcogenide Nanocrystals for the Detection of Carcino Embryonie Antigen

Abstract

In this work, a sandwich-type electrochemical immunosensor was fabricated for the detection of carcino embryonie antigen (CEA) with the novel label of Cu2ZnSnS4 nanocrystals. They illustrated efficient intrinsic peroxidase-like activity to catalytic reduction of peroxide hydrogen, which was ascribed to the synergistic effect of elemental composition in quaternary chalcogenides. Meanwhile, because of high specific surface and good biocompatibility, three-dimensional Au nanoparticles loaded graphene aerogels were selected as substrate to capture more antibodies (Ab1). Under optimal conditions, the immunosensor exhibited wide linear range from 0.5 pg mL-1 to 20 ng mL-1 with a low detection limit of 0.15 pg mL-1 (S/N=3) for CEA detection. In addition, high sensitivity, excellent selectivity, good reproducibility and stability were obtained for the immunosensor. All of these results show that the novel immunosensor has a promising application for quantitative detection of CEA in clinical diagnosis.

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Publication details

The article was received on 23 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Paper
DOI: 10.1039/C7NJ02253K
Citation: New J. Chem., 2017, Accepted Manuscript
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    A Novel Sandwich-type Immunosensor Based on Three Dimensional Graphene-Au Aerogels and Quaternary Chalcogenide Nanocrystals for the Detection of Carcino Embryonie Antigen

    L. Liu, R. Du, Y. Zhang and X. yu, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ02253K

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