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Issue 17, 2017
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A novel sandwich-type immunosensor based on three-dimensional graphene–Au aerogels and quaternary chalcogenide nanocrystals for the detection of carcino embryonic antigen

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Abstract

In this work, a sandwich-type electrochemical immunosensor was fabricated for the detection of carcino embryonic antigen (CEA) with the novel label of quaternary chalcogenide nanocrystals – Cu2ZnSnS4. They illustrated efficient intrinsic peroxidase-like activity in the catalytic reduction of peroxide hydrogen, which was ascribed to the synergistic effect of elemental composition in quaternary chalcogenides. Meanwhile, because of a high specific surface and good biocompatibility, three-dimensional Au nanoparticle loaded graphene aerogels were selected as substrates to capture more antibodies (Ab1). Under optimal conditions, the immunosensor exhibited a wide linear range from 0.5 pg mL−1 to 20 ng mL−1 with a low detection limit of 0.15 pg mL−1 (S/N = 3) for CEA detection. In addition, high sensitivity, excellent selectivity, good reproducibility and stability were obtained for the immunosensor. All of these results show that the novel immunosensor has a promising application for the quantitative detection of CEA in clinical diagnosis.

Graphical abstract: A novel sandwich-type immunosensor based on three-dimensional graphene–Au aerogels and quaternary chalcogenide nanocrystals for the detection of carcino embryonic antigen

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Publication details

The article was received on 23 Jun 2017, accepted on 10 Jul 2017 and first published on 10 Jul 2017


Article type: Paper
DOI: 10.1039/C7NJ02253K
Citation: New J. Chem., 2017,41, 9008-9013
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    A novel sandwich-type immunosensor based on three-dimensional graphene–Au aerogels and quaternary chalcogenide nanocrystals for the detection of carcino embryonic antigen

    L. Liu, R. Du, Y. Zhang and X. Yu, New J. Chem., 2017, 41, 9008
    DOI: 10.1039/C7NJ02253K

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