Jump to main content
Jump to site search

Issue 23, 2017
Previous Article Next Article

Aqueous synthesis of dual-targeting Gd-doped CuInS2/ZnS quantum dots for cancer-specific bi-modal imaging

Author affiliations

Abstract

Dual targeting towards cellular receptors specific to tumors is an important approach for cancer diagnosis. In this work, we demonstrated the aqueous synthesis of Gd3+-doped CuInS2/ZnS (CIGS/ZnS) quaternary quantum dots (q-dots), which combine the functions of fluorescence and magnetic resonance imaging, via a microwave method. To enhance the tumor-targeting ability, 3-aminophenyl-boronic acid (APBA) and folic acid (FA) moieties were conjugated with the CIGS/ZnS q-dots, and act as dual-targeting ligands to generate CIGS/ZnS@FA|APBA q-dots. In vitro fluorescence imaging and cellular internalization of such q-dots were scrutinized with confocal microscopy, as well as magnetic resonance imaging, which revealed specifically targeted in vitro delivery into HeLa cells containing abundant sialic acid and overexpression of folate receptors on the cell surfaces. As compared to CdTe quantum dots, the formed CIGS/ZnS@FA|APBA q-dots displayed lower in vitro cytotoxicity for both HeLa and HepG2 cells according to the MTT assay. The results also showed that these q-dots neither induce any noticeable abnormalities, nor affect the survival or hatching rate in the embryonic and larval development of zebrafish. More importantly, fluorescence imaging revealed that CIGS/ZnS q-dots at concentrations up to 1000 μg mL−1 were excreted from the zebrafish without a significant effect on growth.

Graphical abstract: Aqueous synthesis of dual-targeting Gd-doped CuInS2/ZnS quantum dots for cancer-specific bi-modal imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 23 Jun 2017, accepted on 18 Oct 2017 and first published on 20 Oct 2017


Article type: Paper
DOI: 10.1039/C7NJ02252B
Citation: New J. Chem., 2017,41, 14161-14170
  •   Request permissions

    Aqueous synthesis of dual-targeting Gd-doped CuInS2/ZnS quantum dots for cancer-specific bi-modal imaging

    G. Gedda, G. Chen, Y. Yao, W. M. Girma, J. Li, C. Yen, Y. Ling and J. Chang, New J. Chem., 2017, 41, 14161
    DOI: 10.1039/C7NJ02252B

Search articles by author

Spotlight

Advertisements