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Issue 19, 2017
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Self-assembly of a novel Cu(II) coordination complex forms metallo-vesicles that are able to transfect mammalian cells

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Abstract

Herein, we report the synthesis of amphiphilic bis-(4-pyridylmethyl hexadecanoate)-(1,4,7-triazacyclononane) copper(II) triflate, referred to as Complex 1, which forms metallo-vesicles in water by exploiting the principles of supramolecular chemistry. Extruded metallo-vesicles showed an average particle size of about 33 nm, which was revealed by transmission electron microscopy. The 50% cytotoxic concentration (CC50) of Complex 1 was determined to be 1.25 mM in human embryonic kidney cells (HEK 293-T), and through flow cytometry, it was revealed that these metallo-vesicles could deliver a reporter gene pEGFPN1 to HEK 293-T cells measured. In addition, a non-amphiphilic structural analog, namely bipyridine-(1,4,7-triazacyclononane) copper(II) triflate, hereafter called Complex 2, was synthesized and characterized by X-ray crystallography to reveal the coordination sphere around the copper(II) ion in Complex 1. This study suggests that transition metal-mediated self-assembly can be employed to form low-cost complex nanoparticles having low toxicity and gene transfection properties.

Graphical abstract: Self-assembly of a novel Cu(ii) coordination complex forms metallo-vesicles that are able to transfect mammalian cells

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Publication details

The article was received on 16 Jun 2017, accepted on 15 Aug 2017 and first published on 15 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ02161E
Citation: New J. Chem., 2017,41, 11230-11237
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    Self-assembly of a novel Cu(II) coordination complex forms metallo-vesicles that are able to transfect mammalian cells

    S. Pal, M. T. Islam, J. T. Moore, J. Reyes, A. Pardo, A. Varela-Ramirez and J. C. Noveron, New J. Chem., 2017, 41, 11230
    DOI: 10.1039/C7NJ02161E

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