Revealing the biodistribution and clearance of Ag2Se near-infrared quantum dots in mice

Xiao-Lei Ge; Zhi-Ling Zhang; Zhi-Xiong Xie; Ran Cui; Dai-Wen Pang

doi:10.1039/C7NJ02126G

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Revealing the biodistribution and clearance of Ag₂Se near-infrared quantum dots in mice†

Xiao-Lei Ge,^a Zhi-Ling Zhang,^a Zhi-Xiong Xie,^b Ran Cui

*^a and Dai-Wen Pang^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Research Center for Nanobiology and Nanomedicine (MOE 985 Innovative Platform), State Key Laboratory of Virology, and Wuhan Institute of Biotechnology, Wuhan University, Wuhan 430072, P. R. China
E-mail: cuiran@whu.edu.cn
Tel: +86 27 68756759

^b College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China

Abstract

The biodistribution and clearance in mice of near-infrared (NIR) ultra-small Ag₂Se quantum dots (QDs) were systematically studied. The ICP-MS quantitative assessment and biodistribution fluorescent images of Ag₂Se QDs in mouse organs demonstrated that the Ag₂Se QDs could be cleared quickly from the mice body mostly by renal excretion without significant long-term organs accumulation. Pathological analysis, blood biochemical analysis, and body weight results also showed that the Ag₂Se QDs do not cause appreciable toxicity in vivo.

Download options Please wait...

Supplementary files

Supplementary information PDF (445K)

Article information

DOI: https://doi.org/10.1039/C7NJ02126G
Article type: Paper
Submitted: 13 Jun 2017
Accepted: 12 Sep 2017
First published: 18 Sep 2017

Download Citation

New J. Chem., 2017,41, 12721-12725

Permissions

Request permissions

Revealing the biodistribution and clearance of Ag₂Se near-infrared quantum dots in mice

X. Ge, Z. Zhang, Z. Xie, R. Cui and D. Pang, New J. Chem., 2017, 41, 12721 DOI: 10.1039/C7NJ02126G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

New Journal of Chemistry