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Issue 19, 2017
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One-pot synthesis of N-substituted pyrroles from nitro compounds and 2,5-hexadione over a heterogeneous cobalt catalyst

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Abstract

In this study, the one-pot heterocyclization of nitro compounds with 2,5-hexadione was studied for the synthesis of N-substituted pyrroles via a Paal–Knorr condensation process. The heterogeneous cobalt–nitrogen catalyst (Co–Nx/C-800-AT) was found to be active for this reaction with formic acid. Formic acid served as a hydrogen donor for the transfer hydrogenation, and also acted as an acid catalyst. More importantly, this method was tolerant of other functional groups, and hence various N-substituted pyrroles were produced with good to excellent yields. The Co–Nx/C-800-AT catalyst was highly stable, and could be reused several times without loss of its catalytic activity.

Graphical abstract: One-pot synthesis of N-substituted pyrroles from nitro compounds and 2,5-hexadione over a heterogeneous cobalt catalyst

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Publication details

The article was received on 30 May 2017, accepted on 11 Aug 2017 and first published on 11 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01898C
Citation: New J. Chem., 2017,41, 10613-10618
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    One-pot synthesis of N-substituted pyrroles from nitro compounds and 2,5-hexadione over a heterogeneous cobalt catalyst

    Z. Gong, Y. Lei, P. Zhou and Z. Zhang, New J. Chem., 2017, 41, 10613
    DOI: 10.1039/C7NJ01898C

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