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Issue 18, 2017
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Ruthenium(II) arene complexes showing DNA photobinding: the role of the basicity of the monodentate ligand

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Abstract

Herein, a series of Ru(arene) complexes, [(η6-p-cymene)Ru(bpy)(X)]2+ complexes (bpy = 2,2′-bipyridine, X = pyridine, diazine, pyrimidine, and pyrazine) was synthesized, and its photochemical and photobiological properties were carefully compared. It has been found that the basicity of the monodentate ligand has a significant impact on the ligand photodissociation and photobinding DNA abilities of the complexes. A decrease in the basicity of the monodentate ligand leads to a decrease in the electron donating ability of the monodentate ligand; this enhances the photoinduced DNA covalent binding capabilities of 1–4. The CCK8 assay suggests that 4 exhibits the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. By changing the basicity of the monodentate ligand, the photobinding abilities increases from the complexes 1 to 4; this provides a good strategy for the development of more efficient metallodrugs with photoactivity.

Graphical abstract: Ruthenium(ii) arene complexes showing DNA photobinding: the role of the basicity of the monodentate ligand

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Publication details

The article was received on 27 May 2017, accepted on 31 Jul 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01864A
Citation: New J. Chem., 2017,41, 10225-10230
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    Ruthenium(II) arene complexes showing DNA photobinding: the role of the basicity of the monodentate ligand

    Y. Chen, X. Luo, L. Bai, X. Hu, J. Zhou, P. Zhang and Y. Yu, New J. Chem., 2017, 41, 10225
    DOI: 10.1039/C7NJ01864A

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