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Ruthenium(II) Arene Complexes Showing DNA Photobinding: The Role of the Basicity of Monodentate Ligand

Abstract

A series of Ru(arene) complexes, [(η6-p-cymene)Ru(bpy)(X)]2+ complexes (bpy=2,2’-bipyridine, X= pyridine, diazine, pyrimidine, pyrazine) were synthesized; and their photochemical and photobiological properties were compared carefully. It was found that the basicity of monodentate ligand has a significant impact on ligand photodissociation and photobinding DNA abilities of the complexes. Decreasing the basicity of monodentate ligand, the electron donating ability of monodentate ligand decreased, led to the enhencement of photoinduced DNA covalent binding capabilities from 1 to 4. CCK8 assay suggest that 4 has the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. By changing the basicity of monodentate ligand, the photobinding abilities of the complexes incresed from 1 to 4, providing a good strategy for developing more efficient metallodrugs with photoactivity.

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Publication details

The article was received on 27 May 2017, accepted on 31 Jul 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01864A
Citation: New J. Chem., 2017, Accepted Manuscript
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    Ruthenium(II) Arene Complexes Showing DNA Photobinding: The Role of the Basicity of Monodentate Ligand

    Y. Chen, X. Luo, L. Bai, X. Hu, J. Zhou, P. Zhang and Y. Yu, New J. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7NJ01864A

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