Jump to main content
Jump to site search

Issue 14, 2017
Previous Article Next Article

Synthesis of pyridine-alkoxide ligands for formation of polynuclear complexes

Author affiliations

Abstract

We have prepared and characterized a series of novel polydentate N,O-donor ligands derived from our well-studied ligand 2-(2-pyridinyl)-2-propanol (pyalkH), having the general formula Me{C(OH)(2-py)CH2}nH, where n = 2 or 3. Like pyalkH, these analogues bind via N and O with deprotonation at the latter, thus extending the strongly donor pyridine-alkoxide chelation power of pyalkH to polydentate forms. The greater denticity allows for more effective binding and polynuclear cluster formation with first-row transition metals. Several stable alkoxo-bridged polynuclear clusters of these ligands with Mn, Cu, Co and Ni have been prepared; all reported ligands and complexes have been characterized, including by X-ray crystallography. We report a one-step synthesis of these ligands, alongside pyalkH, on a multi-gram scale from inexpensive starting materials. We have also developed a new scalable procedure for the isolation of pyalkH that avoids the need for chromatography, making large-scale production of this ligand commercially viable.

Graphical abstract: Synthesis of pyridine-alkoxide ligands for formation of polynuclear complexes

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 May 2017, accepted on 09 Jun 2017 and first published on 12 Jun 2017


Article type: Paper
DOI: 10.1039/C7NJ01845B
Citation: New J. Chem., 2017,41, 6709-6719
  •   Request permissions

    Synthesis of pyridine-alkoxide ligands for formation of polynuclear complexes

    D. Y. Shopov, L. S. Sharninghausen, S. B. Sinha, J. E. Borowski, B. Q. Mercado, G. W. Brudvig and R. H. Crabtree, New J. Chem., 2017, 41, 6709
    DOI: 10.1039/C7NJ01845B

Search articles by author

Spotlight

Advertisements