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Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

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Abstract

Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain-promoted azide–alkyne (SPAAC) cycloaddition and either a polyethylene glycol or a glucose moiety to ensure MNP stability in physiological media. Their reactivity towards azide-functionalised Si surfaces was investigated, demonstrating their potential as bioorthogonal probes.

Graphical abstract: Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

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Publication details

The article was received on 24 May 2017, accepted on 16 Aug 2017 and first published on 16 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01822C
Citation: New J. Chem., 2017, Advance Article
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    Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

    R. M. Fratila, M. Navascuez, J. Idiago-López, M. Eceiza, J. I. Miranda, J. M. Aizpurua and J. M. de la Fuente, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01822C

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