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Issue 20, 2017
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A novel label-free electrochemical immunosensor based on the composite of LPCs-SnS2 and AuNPs for the detection of human chorionic gonadotropin

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Abstract

In this study, a novel label-free electrochemical immunosensor was constructed with new layered SnS2 functionalized lignin-based porous carbons (LPCs-SnS2) and gold nanoparticles (AuNPs) as substrates for the sensitive and fast detection of human chorionic gonadotropin (hCG). Vertical SnS2 nanosheet arrays were orderly loaded on LPCs via a facile hydrothermal route, which resulted in a 3D conduction architecture and a large surface area. Based on the high performance of the AuNPs/LPCs-SnS2 composite, an hCG electrochemical immunosensor was successfully fabricated with a wide linear response in the range of 0.5–50 ng mL−1 and a limit of detection of 6.4 pg mL−1. The proposed immunosensor displayed good specificity, reproducibility and stability. And finally, it was successfully used for the detection of hCG in a real human serum sample.

Graphical abstract: A novel label-free electrochemical immunosensor based on the composite of LPCs-SnS2 and AuNPs for the detection of human chorionic gonadotropin

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Publication details

The article was received on 22 May 2017, accepted on 28 Aug 2017 and first published on 28 Aug 2017


Article type: Paper
DOI: 10.1039/C7NJ01774J
Citation: New J. Chem., 2017,41, 11600-11606
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    A novel label-free electrochemical immunosensor based on the composite of LPCs-SnS2 and AuNPs for the detection of human chorionic gonadotropin

    H. Wang, W. Guo and M. Pei, New J. Chem., 2017, 41, 11600
    DOI: 10.1039/C7NJ01774J

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