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Polyglycolide–montmorillonite as a novel nanocomposite platform for biosensing applications

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Abstract

In catalytic biosensors, the immobilization of biomolecules in a suitable matrix is one of the vital parameters for obtaining improved systems. Clays, which are intercalated with various organic compounds, have a great tendency to develop biosensors with high stability, sensitivity and reproducibility. Herein, a polymer/clay nanocomposite based on natural silicate montmorilonite (Mt) and a biodegradable polymer polyglycolide (PGA) was prepared and characterized by FT-IR, thermogravimetric analysis, differential thermogravimetric analysis and X-ray diffraction. Then, the resulting matrix was used as a fixation matrix for pyranose oxidase (POx), which was selected as a model enzyme. The bioactive layer was fabricated by immobilization of POx on glassy carbon electrodes by means of PGA–Mt and bovine serum albumin. The POx biosensor revealed a good linear range from 0.01 to 0.5 mM glucose with a LOD of 1.2 μM. After the optimization of the working and preparation conditions, characterization studies were performed for glucose detection. Finally, the PGA–Mt/POx biosensor was confirmed to have detected glucose in beverages without needing any sample pre-treatment.

Graphical abstract: Polyglycolide–montmorillonite as a novel nanocomposite platform for biosensing applications

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Publication details

The article was received on 19 May 2017, accepted on 24 Jul 2017 and first published on 25 Jul 2017


Article type: Paper
DOI: 10.1039/C7NJ01751K
Citation: New J. Chem., 2017, Advance Article
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    Polyglycolide–montmorillonite as a novel nanocomposite platform for biosensing applications

    B. Unal, E. E. Yalcinkaya, S. Gumustas, B. Sonmez, M. Ozkan, M. Balcan, D. O. Demirkol and S. Timur, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01751K

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