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Electrochemical behaviour of several penicillins at high potential

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Abstract

Electrochemical oxidation at high potential, using a bare boron-doped diamond electrode as the working electrode was evaluated for five penicillins: oxacillin, penicillin V, penicillin G, ampicillin and amoxicillin. Even though the electrochemical oxidation is expected to occur at the common penicillin core, the five molecules exhibited different electrochemical behaviour, even after alkaline or acid hydrolysis. Based on anodic oxidation at high potential, a simple electrochemical method was developed for the detection of oxacillin by differential pulse voltammetry. Different electrode materials and electrode modifications were tested, with the best results being obtained with the unmodified boron-doped diamond electrode. The developed method allows a selective detection of oxacillin, with low influence from common interferents and is sensitive enough to be successfully applied to oxacillin detection from pharmaceutical, biomedical and environmental samples. The anodic oxidation of penicillins was successfully adapted for flow injection analyses, with sensitive and reproducible successive analyses of oxacillin, at different concentrations.

Graphical abstract: Electrochemical behaviour of several penicillins at high potential

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Publication details

The article was received on 18 May 2017, accepted on 16 Sep 2017 and first published on 20 Sep 2017


Article type: Paper
DOI: 10.1039/C7NJ01729D
Citation: New J. Chem., 2017, Advance Article
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    Electrochemical behaviour of several penicillins at high potential

    B. Feier, I. Ionel, C. Cristea and R. Săndulescu, New J. Chem., 2017, Advance Article , DOI: 10.1039/C7NJ01729D

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